Uneven triple agonism
In cell assays, retatrutide showed balanced glucagon and GLP-1 receptor activity but stronger GIP activity; in obese mice, the glucagon arm added energy expenditure.
Coskun et al., Cell Metabolism, 2022
In stockGLP-3-RT
A triple-receptor agonist studied for its activity at GLP-1, GIP, and glucagon receptors. Our Retatrutide is supplied as a high-purity research peptide with independent testing for identity and purity. For laboratory research use only.
99.76% purity · HPLC Lot TC-079-JZ White Lyophilized Powder
$79.99 $79.99 per 10MG vial
Size: 10MG
- Third-party tested · COA for this lot
- Ships same day when ordered before 3 PM ET
- Free shipping on orders over $49.99
- Questions? Contact support — 860-681-6522
For laboratory research use only. Not for human or animal consumption.
Overview
About GLP-3-RT
Retatrutide (LY3437943) is Eli Lilly's single molecule that activates three receptors: GIP, GLP-1 and glucagon. Hence the GLP-3 retatrutide nickname, though no hormone called GLP-3 exists. A C20 fatty-acid chain on lysine 17 lets it ride on albumin for days. Lilly's phase 3 TRIUMPH program is testing it at scale, with TRIUMPH-1 and TRIUMPH-3 reaching primary completion in April 2026.
That fame brings copies. A 2026 preprint by Mendias and Awan, covering 6,441 independent test reports, found 59 retatrutide samples that didn't contain retatrutide, the most of any compound. Australia's TGA reported in September 2026 on a vial sold as retatrutide that held semaglutide. No substitute matches retatrutide's mass with that lipid chain attached, so mass spectrometry exposes a swap at once. Titan Core makes retatrutide in the USA and tests every batch for identity and purity by mass spec and HPLC; the downloadable report carries your vial's LOT number. Some sellers list this compound under code names without naming the molecule. We publish its name, sequence and CAS. It's for laboratory research only, not for human or animal use.
Research highlights
What the literature reports
Once-weekly kinetics
A phase 1b study in 72 adults with type 2 diabetes found dose-proportional pharmacokinetics and a half-life near six days.
Urva et al., The Lancet, 2022
Liver fat research
A 98-participant substudy in steatotic liver disease tracked liver fat at 24 and 48 weeks alongside insulin-sensitivity and lipid measures.
Sanyal et al., Nature Medicine, 2024
Kidney biomarkers
In type 2 diabetes, the 12 mg arm cut urine albumin-to-creatinine ratio 37.0% versus placebo at 36 weeks, eGFR unchanged.
Heerspink et al., Kidney International Reports, 2025
A dedicated CKD trial
TRANSCEND-CKD randomized 146 adults with obesity and kidney disease to measure GFR by iohexol clearance at week 24.
Heerspink et al., Nephrology Dialysis Transplantation, 2026
Glucagon arm and lipids
In human liver cells, retatrutide lowered ANGPTL3/8 secretion, and a glucagon-receptor antibody blocked the effect.
Wen et al., Diabetes, Obesity and Metabolism, 2025
Cardiovascular biomarkers
Phase 2 analyses recorded apolipoprotein B falls of 21.4% and 24.2% in two studies.
Ruotolo et al., Diabetes, Obesity and Metabolism, 2026
Specifications
Product details
- Form
- Lyophilized powder
- Purity
- ≥99% (HPLC verified)
- Molecular formula
- C₂₂₁H₃₄₂N₄₆O₆₈
- Molecular weight
- 4731.4 g/mol
- CAS number
- 2381089-83-2
- Presentation
- 10mg · 20mg · 30mg · 50mg
- Lot
- TC-079-JZ
- Storage
- Store lyophilized at –20°C, protected from light and moisture.
Amino-acid sequence
Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-αMeLeu-Leu-Asp-Lys-Lys(AEEA-γGlu-C20 diacid)-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂
At a glance
- Third-Party Tested - (COA) Available
- Free 2-Day Shipping on Orders $49.99
- Lipidated Lysine-17 Side Chain Specified
FAQ
Frequently asked questions
A synthetic 39-amino-acid peptide from Eli Lilly, coded LY3437943, that activates GIP, GLP-1 and glucagon receptors from one molecule.
Researchers use it to study three metabolic pathways at once: insulin and appetite signaling through GIP and GLP-1, and energy expenditure through glucagon.
Tirzepatide stops at two receptors, GIP and GLP-1. Retatrutide adds the glucagon receptor, giving researchers an energy-expenditure pathway tirzepatide doesn't touch.
Only partly. Ozempic's semaglutide works on the GLP-1 receptor alone; retatrutide hits three receptors and is a different, heavier molecule.
Download the report here and match its LOT to your vial. HPLC shows purity; the mass result confirms retatrutide rather than another GLP-1 peptide. If the LOTs differ, contact support before opening it.
Questions about retatrutide side effects are answered by Lilly's clinical trials, not by a research vial. Titan Core's retatrutide is a research compound, not an approved medicine, and we don't give dosing or safety guidance for people.
Right here. To buy retatrutide, register, pick a size and check out. Our retatrutide for sale is USA-made, and weekday orders placed by 4 PM EST ship the same day.
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